Abstract
The article describes current concepts of the role of cytokines in the pathogenesis of inflammatory diseases. The authors describe the biological action of tumor necrosis factor-alpha and its soluble receptors on body cells. They also provide data on the role of tumor necrosis factor-alpha in the formation of skin and joint inflammatory affections at psoriasis. The authors substantiate treatment of medium to severe forms of psoriasis with biological gene-engineered anti-cytokine drugs, and provide and their comparative characteristics.
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