Abstract
AbstractA library of over 103 thousand compounds was screened for inhibitors of the IspD domain (2‐C‐methyl‐d‐erythritol 4‐phosphate cytidylyl transferase domain) of the bifunctional IspDF protein fromHelicobacter pyloriusing a photometric assay. Around 300 compounds showedIC50values below 100 μm, and three compounds hadIC50values below 1 μm. A few IspD inhibitors could also inhibit the IspF domain (2‐C‐Methyl‐d‐erythritol‐2,4‐cyclopyrophosphate synthase) of the IspDF protein. The most potent IspD inhibitors were tested as growth inhibitors ofH. pylori. Several compounds showed inhibition of bacterial growth withIC50in the single‐digit μmrange. The most potent growth inhibitor had anIC50value of 3.4 μm. The most potent growth inhibitor without measurable effect on eukaryotic cell viability had anIC50value of 7.2 μm.
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