Abstract
The agglutinability mediated by concanavalin A has been studied in the zona-free mouse oocyte before and after fertilization or treatment with inhibitors of protein synthesis. At lectin concentrations of 10 μg/ml ot higher the zygote is clearly more agglutinable than the unfertilized oocyte. Treatment with 10 μg/ml of cycloheximide or puromycin, which causes parthenogenetic activation, greatly increases the agglutinability of the unfertilized oocyte; the agglutinability of the zygote and of the early blastocyst is not increased by such treatment. The possibility is discussed that the repression of cell division requires the synthesis of unstable protein molecules of the cell surface which are also involved in lectinmediated agglutinability.
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