Inhibitors of Protein Kinases and Protein Phosphates

Abstract

Protein Kinase Inhibitors for the Treatment of Disease: The Promise and the Problems.- General Aspects of PKs Inhibition.- New Design Strategies for Ligands That Target Protein Kinase-Mediated Protein-Protein Interactions.- Pharmacological Potential and Inhibitors of Individual Classes of Protein Kinases.- The Paullones: A Family of Pharmacological Inhibitors of Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3.- Pharmacological Potential of p38 MAPK Inhibitors.- Inhibitors of PKA and Related Protein Kinases.- Inhibitors of Protein Kinase CK2: Structural Aspects.- Aminoglycoside Kinases and Antibiotic Resistance.- Pharmacological Potential and Inhibitors of Individual Classes of Protein Phosphatases.- Protein Tyrosine Phosphatases as Therapeutic Targets.- Structure-Based Design of Protein Tyrosine Phosphatase Inhibitors.- Biological Validation of the CD45 Tyrosine Phosphatase as a Pharmaceutical Target.- Serine/Threonine Protein Phosphatase Inhibitors with Antitumor Activity.- Inhibitors in Clinical Use or Advanced Clinical Trials.- Clinical Immunosuppression using the Calcineurin-Inhibitors Ciclosporin and Tacrolimus.- Targeted Therapy with Imatinib: An Exception or a Rule?.- Clinical Aspects of Imatinib Therapy.- Isoquinolinesulfonamide: A Specific Inhibitor of Rho-Kinase and the Clinical Aspect of Anti-Rho-Kinase Therapy.- Discovery and Development of Iressa: The First in a New Class of Drugs Targeted at the Epidermal Growth Factor Receptor Tyrosine Kinase.