Abstract
SINCE HYALURONIDASE, an enzyme prepared from mammalian testes or spermatozoa, was found capable of readily dispersing the follicle cells of freshly ovulated mammalian ova without apparent injury to the egg (McClean and Rowlands, 1942; Fekete and Duran- Reynals, 1943; Leonard and Kurzrok, 1945), new concepts on problems of fertility and sterility have arisen. These observations have led to the suggestion that the relatively large numbers of sperm in an ejaculate are necessary to attain a sufficiently high concentration of hyaluronidase in order that the tightly adhering follicle cells can be removed for sperm penetration and in time before degeneration of the ovum. Rowlands (1944) succeeded in artificially inseminating and fertilizing rabbits with dilute sperm suspensions provided the enzyme from killed sperm was added. Without the enzyme, no fertilization occurred. Leonard and Kurzrok (1945) reported that it was possible to artificially inseminate and fertilize women by adding bull-testis hyaluronidase to...
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