Abstract
Previous studies of the role of inhibitors of calcium oxalate and calcium phosphate crystal formation in urine have usually been performed either in relatively simple aqueous solutions or by addition of dilute urine samples to solutions supersaturated for calcium oxalate or phosphate1–4. These experiments however are open to serious objections: 1) Urine contains macromolecular promoters of crystal formation, probably uromucoids5, which should be included but have previously been excluded, and 2) the effect of certain inhibitors, notably pyrophosphate, citrate and methylene blue on calcium oxalate and calcium phosphate crystal formation is much less in whole urine than in simple inorganic solutions6. Even the studies of whole urine have not been physiological because they relied on addition of calcium and oxalate (or phosphate) to urine and this procedure can lead to abnormal crystal habits7.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
