Inhibitors of adenosine 3',5'-cyclic monophosphate phosphodiesterase in Daphne genkwa Sieb. et Zucc.

Abstract

Luteolin, luteolin-7-methylether and kaempferol 3-O-β-D- (6″-p-coumaroyl) glucopyranoside (tiliroside) were identified as adenosine 3′, 5′-cyclic monophosphate phosphodiesterase inhibitors contained in the flowers and buds of Daphne genkwa SIEB. et ZUCC. The assignments of the proton and carbon-13 nuclear magnetic resonance signals of tiliroside were confirmed by two-dimensional 1H-13C chemical shift correlation spectroscopy.