Inhibitors of β-Amyloid Formation Based on the β-Secretase Cleavage Site

Abstract

A series of inhibitors of β-amyloid formation have been developed based on the β-secretase cleavage site (VNL-DA) of the Swedish mutant Amyloid Precursor Protein. A simple tripeptide aldehyde was found to be the most potent (IC50 = 700 nM) in the series displaying an inhibitory profile which is different from reported inhibitors of β-amyloid formation.