"Inhibitors and Mechanisms of Solanine and Curdione on HIF-1α in Renal Carcinoma Xenograft and Human Renal Carcinoma ACHN Cells"

Yidong Wang

doi:10.26717/bjstr.2021.35.005764

Abstract

"Inhibitors and Mechanisms of Solanine and Curdione on HIF-1α in Renal Carcinoma Xenograft and Human Renal Carcinoma ACHN Cells"

Highlights

Hypoxia-inducible factor-1 (HIF-1) is a protein complex composed of two similar subunits, Hypoxia-inducible factor 1α (HIF-1α) and HIF-1β
The results showed that the relative expression rate of HIF-1α protein in ACHN cells treated with Solanine and Curdione decreased compared with the control group (P < 0.05), and the combined administration of Solanine and Curdione had a more significant down-regulation effect on HIF-1α protein (P < 0.01)
The results showed that the HIF-1α protein expression in tumor block tissues of the Solanine and or Curdione intervention group was significantly decreased compared with the blank control group (P < 0.05), and the decrease in the combination group was more significant than that in the single drug intervention group

Summary

Introduction

Hypoxia-inducible factor-1 (HIF-1) is a protein complex composed of two similar subunits, HIF-1α and HIF-1β. HIF-1α is a hypoxia-induced transcription factor that is present at high levels in malignant solid tumors, but not in normal tissues or slow-growing tumors. In fast-growing tumors, HIF-1α is involved in the activation of a number of cellular processes, including resistance to apoptosis, overexpression of the drug envelope pump, vascular remodeling and angiogenesis, and metastasis. HIF-1α induces overexpression and enhanced activity of several glycolytic protein subtypes. Previous studies have found that Solanine and Curdione can inhibit the growth of kidney energy metabolism process of interference with, but the specific mechanism is unclear, to explore the Solanine, Curdione, the function of kidney HIF - 1 alpha and further study of related mechanisms, for the development and application of Solanine, Curdione has important value, and Solanine, Curdione will be safe and effective prevention and control of malignant tumor of cheap drugs [1-3]

Objectives

Methods

Results

Conclusion