Abstract
Dysregulation of transcriptional control is a common mechanism driving oncogenesis. Microenvironment is a critical factor promoting myelomagenesis, tumor growth and drug resistance by impacting myeloma transcriptome. Here, we used RNA-sequencing of multiple myeloma (MM) cells cultured with stromal cell line HS-5 to identify transcriptional changes enhancing MM cell proliferation. We identified a reproducible and significant downregulation of inhibitor of DNA binding 2 (ID2), a known regulator of transcription through heterodimerization with basic HLH (bHLH) proteins and inhibition of their binding to DNA, across various MM cell lines in presence of stroma.
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