Abstract
The inhibitory effects of desipramine and some related agents on the uptake of tritiated noradrenaline in slices of cerebral cortex of the mouse and the uptake of tritiated dopamine in slices of the corpus striatum of the rabbit were investigated. The effect of the drugs, administered in vivo, on the uptake of noradrenaline was compared with their antagonizing effect on the decrease of motor activity (sedation), ptosis and hypothermia produced by reserpine and tetrabenazine. In vitro, all the agents with the exception of UCB 6249 inhibited the uptake of the catecholamines. Lu 3-010, desipramine and imipramine were considerably more powerful in inhibiting the uptake of noradrenaline than of dopamine. In vivo, only these compounds and (±)-amphetamine inhibited the uptake of noradrenaline and antagonized the ptosis and hypothermia produced by reserpine, and the ptosis induced by tetrabenazine. UCB 6249 antagonized sedation and ptosis produced by tetrabenazine but not by reserpine.
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