Inhibition of the transport of d-tubocurarine from blood to bile by k-strophantoside in the isolated perfused rat liver

Abstract

The biliary excretion of d-tubocurarine was studied in experiments with the isolated perfused rat liver preparation. On the administered dose 31–44% is excreted unchanged during perfusions of two hours. The compound moves from blood to bile against a large concentration gradient, with bile-to-blood concentration ratios of 94–190. The transport of d-tubocurarine to bile can be blocked by k-strophantoside in a concentration of ca. 2×10 −5M. The possible role of Na +KK +-activated ATPase in the active transport process of the bis-quaternary ammonium compound is discussed.