Abstract
Previous work from our laboratory suggests that one mechanism of ammonium transport across the intestinal membrane may be substitution of ammonium for sodium in the sodium/hydrogen antiport. This study further supports this mechanism by demonstrating an inhibitory role for ammonium in the sodium/hydrogen exchange. Whole brush border intestinal enterocytes were studied, incorporating a fluorescent marker for sodium transport. The kinetics of the effect of ammonium on sodium transport were determined. Ammonium is an inhibitor of sodium in the sodium/hydrogen exchanger. Quantitatively, the inhibition appears to be competitive. The inhibitory effect of ammonium on sodium/hydrogen exchange supports a mechanism of ionized ammonium transport where it substitutes for sodium in the sodium/ hydrogen exchanger. This is a mechanism by which hyperchloremic metabolic acidosis occurs following urinary intestinal diversion.
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