Abstract
The administration of chlorpromazine to mice inhibits in vitro the activity of a liver enzyme that N-methylates nicotinamide. Inhibition of nicotinamide methylation was also observed after the addition in vitro of chlorpromazine to a 25-fold purified enzyme isolated from rat liver. Kinetic studies indicated that this inhibition was due to a marked reduction in the affinity constant of the enzyme for nicotinamide. In the presence of saturating amounts of nicotinamide, chlorpromazine increased rather than decreased the methylation of nicotinamide.
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