Abstract
Growth of malignant plasma cells in multiple myeloma is regulated by the JAK/STAT3 pathway via cytokines such as interleukin(IL)-6 which is produced in the bone marrow microenvironment. IL-6 stimulation leads to upregulation of anti-apoptotic proteins of the Bcl-2 family including Mcl-1 and/or Bcl-xL. Growth of INA-6 plasmacytomas in SCID mice depends on activation of the signal transducer gp130, the common receptor for IL-6 and other cytokines of the IL-6/gp130 family (Burger et al., Haematologica 102, 2017).
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
