Abstract
The present study was conducted to investigate the mode of action of danazoi by monitoring the first ovulation, serum luteinizing hormone (LH) levels and ovarian prostaglandin (PC) F 2α metabolism in pregnant mare serum gonadotropin (PMSG)-primed immature female rats. When danazoi (750 mg/kg) was given p.o. once a day for 5 days (day 24–28), the occurrence of the first ovulation, the increase in capacity to.form 13,14-dihydro-PGF 2α and PGF 2α levels induced by PMSG (5 IU) injected on day 26 were clearly inhibited on day 29. Danazoi also markedly suppressed the LH surge occurring on day 28. Although the danazol-induced blockage of ovulation was restored by injection of human chorionic gonadotropin, the number of oocytes was significantly decreased as compared with that of controls. The present data indicate that the inhibitory actions of danazoi on ovulation and ovarian PGF 2α metabolism may occur via some direct effects on the ovary in addition to the suppression of gonadotropin release from the pituitary gland.
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