Abstract
Nitraminoacetate and the nitronate of nitroacetate are effective inhibitors of beef heart succinate dehydrogenase, respectively binding about 17 and 6.6 times more tightly than succinate at pH 8.0 and 25° as judged by the Km/Ki ratios. Unlike the case of the suicide inactivator 3-nitropropionate, these compounds are freely reversible inhibitors. The toxicity of nitraminoacetate, an antibiotic elaborated by Streptomycesnoursei, may be secondary to the inhibition of the Krebs cycle at the succinate dehydrogenase reaction, and the nitramino group may prove useful as a carboxylate analog for other enzymes.
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