Abstract
Primary, secondary, and tertiary long chain aliphatic amines were synthesized, and their activity against Streptococcus faecalis was determined. Quantitative structure-activity analyses were carried out based on the Hansch extrathermodynamic model, using partition coefficients, CMC's, quantum mechanical charges on the amine nitrogen, and the Taft steric parameter. The best correlations were obtained with the CMC. Steric properties of the ammonium head become important for tertiary amines. The structural feature of these compounds that dominates biological activity is the length of the alkyl tail. Ammonium head substituents are of only secondary importance.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
