Abstract
Urinary bladder neoplasm is one of the most common cancers worldwide. Cancer stem cells (CSCs) have been proven to be an important cause of cancer progression and poor prognosis. In the present study, we established bladder CSCs and identified the crucial differentially expressed genes (DEGs) between these cells and parental bladder cancer cells. Analyses of bioinformatics data and clinical samples from local hospitals showed that stearoyl CoA desaturase‐1 (SCD) was the key factor among the DEGs. A significant correlation between SCD gene expression and poor prognosis among patients with bladder cancer was observed in our data. Loss‐of‐function experiments further revealed that the SCD inhibitor A939572 and SCD gene interference reduced cell proliferation and invasion. The above data suggest that SCD may serve as a novel marker for the prediction of tumour progression and poor prognosis in patients with bladder cancer.
Highlights
In western countries, bladder urothelial cell cancer is the fourth most common malignancy in men
We suggested that Bladder CSCs (BCSCs) are responsible for the poor prognosis of patients with bladder cancer
We elaborated for the first time on the relationship between stearoyl CoA desaturase‐1 (SCD) gene activity and bladder cancer
Summary
Bladder urothelial cell cancer is the fourth most common malignancy in men. The authors identified several implications of the disease and its behaviour and revealed the efficacy of current efforts and measures.[3] Up to 70% of patients with non‐muscle‐invasive bladder. To verify the potential biological functions of SCD in bladder cancer, we performed several cancer‐related assays
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