Abstract
Abstract The effects of saline and hyperoncotic albumin infusion given to dogs during a stable water diuresis were compared. Both inhibited proximal tubule-sodium reabsorption and caused an increase in free water clearance. Only saline caused a rise in the concentration of sodium in the urine. This finding strongly suggests that the saline infusion resulted in inhibition of sodium reabsorption by the loop of Henle. As previously noted, the U Na V rose only slightly after albumin and quite markedly following the saline infusion. These data are interpreted as indicating that more than sodium reabsorption by the proximal tubule (Factor III) is operative in the renal response to a saline infusion.
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