Abstract
The effects of the potassium channel activator, cromakalim, on intestine motility were investigated. In vitro, cromakalim inhibits the peristaltic reflex, with the action on longitudinal muscle (pIC 50 = 5.8 ± 0.1) being more potent than that on circular muscle (pIC 50 = 4.8 ± 0.2). In vivo, a half maximal inhibition of small intestinal transit occurred at 1.2 mg/kg (i.p.). These results demonstrate that different gut muscle layers show a different sensitivity to cromakalim and that small intestine smooth muscle is less sensitive to cromakalim than vascular smooth muscle.
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