Abstract
Introduction IGN311 is a humanized monoclonal IgG1 antibody that binds to the Lewis Y (LeY) carbohydrate overexpressed on epithelial cancers. IGN311 potently mediates human effector functions (ADCC, CDC). The overexpression of fucosyltransferases in tumor cells also results in glycosylation of cell surface receptors by LeY. The anti-LeY antibodies IGN311 and its murine parent version ABL 364 therefore might influence the signaling in tumor cells via inhibition of growth factor receptor functions.
Highlights
IGN311 is a humanized monoclonal IgG1 antibody that binds to the Lewis Y (LeY) carbohydrate overexpressed on epithelial cancers
The overexpression of fucosyltransferases in tumor cells results in glycosylation of cell surface receptors by LeY
The anti-LeY antibodies IGN311 and its murine parent version ABL 364 might influence the signaling in tumor cells via inhibition of growth factor receptor functions
Summary
Inhibition of signaling via erbB-receptors by antibodies that target the Lewis Y-antigen. Address: 1igeneon, Vienna, Austria and 2University of Vienna, Institute of Pharmacology, Vienna, Austria. Published: 1 July 2004 Cancer Cell International 2004, 4(Suppl 1):S23 This article is available from: http://www.cancerci.com/content/4/S1/S23. Association for Immunotherapy of Cancer: Cancer Immunotherapy – 2nd Annual Meeting Meeting abstracts
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