Abstract
Dysfunction of granulosa cells is a major cause of premature ovarian insufficiency (POI), a serious event for women that leads to infertility with unknown etiology. SHP2 is a tyrosine phosphatase that regulates multiple signaling cascades, including G-protein-coupled receptors signaling that plays a significant role in FSH-stimulated steroid synthesis signaling pathway. However, the function of SHP2 in the production of estrogen in granulosa cells and the pathogenesis of POI remains unknown.
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