Abstract
Effects of gamma-endorphin, the mu- and delta-opioid receptor's agonist on amplitude and frequency of reticulo-ruminal contractions of conscious sheep were determined. Gamma-endorphin (1.0 and 2.0 μg kg −1 BW) administered into the third cerebral ventricle caused significant decreases in frequency of reticulo-ruminal contractions. Gamma-endorphin (2.0 μg kg −1 BW) depressed frequency and amplitude, and caused general neuroleptic-like action. A 1.0 μg kg −1 BW dose increased amplitude of contractions and provoked psychomotor-excitability action. Naloxone (12.5 μg kg −1 BW) prevented response to gamma-endorphin. Results suggest that an inhibitory mu- and delta-opioid system is involved in the control of forestomach motility and general behavior in sheep.
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