Abstract
In the present study, rat renal Na +, K +-ATPase was found to be more sensitive to inhibition by high Na + concentrations (100–400 mM) than was rat cardiac Na +, K +-ATPase. K + was more effective in reversing the inhibition by Na +, of cardiac relative to renal Na +, K +-ATPase. Rat renal Na +, K +-ATPase was also more sensitive than cardiac Na +, K +-ATPase to inhibition by vanadate over this range of Na + concentrations. These results support the hypothesis that vanadate may selectively regulate Na +, K +-ATPase in the kidney, and they may also help explain the natriuretic and diuretic effects of vanadate in rats. Inhibition of renal Na +, K +ATPase by Na +, may also help explain, in part, the natriuretic and diuretic effects of acute saline loading.
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