Abstract
Radiotherapy is one of important approaches for pulmonary adenocarcinoma. However, many studies have shown that radiation can also enhance the ability of tumor cells metastasis, although the lung adenocarcinoma could be killed. The increased metastasis induced by radiation is associated with the activation of STAT3 in lung adenocarcinoma cells. Based on the importance role of STAT3 in cell proliferation and survival, we can construct an adenovirus vector of PIAS3 overexpress driven by radiation-induced promoter to inhibit the activation of STAT3 specifically. In this way, when STAT3 was activated by radiation, the expression of PIAS3 will be increased at the same time; this lead to the inhibition of invasion and metastasis caused by STAT3 in lung adenocarcinoma cells. These researches are expected to develop a novel target and method for radiotherapy and molecular therapy of lung adenocarcinoma.
Highlights
How to cite this paper: Gao, L., et al (2014) Inhibition of Radiation-Induced Lung Adenocarcinoma Cell Metastasis by Adenovirus of PIAS3 Overexpression Driven by Radiation-Inducible Promoter (Ad-pig3RRP-PIAS3)
As the radiation-induced activation of STAT3 plays an important role on invasion and metastasis of A549 cells, it can be inferred that PIAS3 played a prominent role in the invasion and metastasis of lung adenocarcinoma cells via STAT3
These results demonstrated that the promoter region of PIG3 gene contains a radiation-sensitive region, which could activate the gene expression of downstream when the cells were irradiated
Summary
It was indicated that radiation can promote the metastasis of pancreatic cancer cells [1] [2], glioma cells [3] [4], hepatoma carcinoma cells [5], breast cancer cells [6], melanoma cells [7], ductal carcinoma cells [8] and lung adenocarcinoma cells [9], the tumor cells can be killed. Radiation was found to activate the phosphorylation of STAT3 which resulted in the increase of invasion of A549 cells [9]. By using special inhibitor to block radiation-induced STAT3 activation, the increase of invasion and migration of A549 cell induced by radiation can be reduced significantly [10]. All above comes down to one point: STAT3 plays a key role in radiation-induced invasion and metastasis and is a potential target of therapy in lung adenocarcinoma
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