Abstract

Objective: To determine the sensitivity, specificity and predictive value of the pyruvate dehydrogenase (PDH) activity inhibition test for the diagnosis of primary biliary cirrhosis (PBC), Design: Application of PDH inhibition test to sera from patients with PBC, clinically and serologically related diseases, chronic liver disease controls and normal controls. Methods: Inhibition of the in vitro activity of PDH by pre-incubation with sera. Results: Pyruvate dehydrogenase activity was inhibited by sera from all patients with PBC, from four out of 41 with chronic active hepatitis, from three out of 35 with progressive systemic sclerosis and from none of those with chronic liver disease, surgical obstructive jaundice or from normal controls

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