Abstract
The effect of several 2-aryl-1,3-indandiones on the biosynthesis of prostaglandin E 2 from arachidonic acid by bovine seminal vesicle microsomes was examined. 2-Phenyl-1,3-indandione appeared to be a weak inhibitor but by introducing electron-withdrawing substituents into the phenyl ring and augmenting lipophilicity, very active compounds were obtained. Activity, however, disappeared entirely on substitution in the ortho position. Inhibition was not related to the presence of an acidic group and was irreversible in some cases. The inhibition of prostaglandin biosynthesis by 2-aryl-1,3-indandiones showed no clear relationship with anti-inflammatory action.
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