Abstract
To investigate the influence of probimane on the lipoperoxidation of human red cells in vitro. Malondialdehyde (MDA) of human red cells induced by hydrogen peroxide was assayed by means of colorimetry. It was shown that probimane (> 2 µM) could inhibit the lipoperoxidation without adriamycin. The inhibitory rates of probimane were 9.3% (2 µM) and 35.3% (10 µM) respectively (P<0.05). Probimane (2 µM) inhibited lipoperoxidation in the presence of sialic acid (0.4 µM) (inhibitory rate 17.8%) was approximately two fold higher than those without sialic acid (inhibitory rate 9.3%). So probimane may inhibit tumor growth through affecting lipoperoxidations and exhibit anticancer effects via sialic acids.
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