Abstract
A monoclonal antibody against progesterone completely blocked pregnancy when rats were injected intraperitoneally at 0.53 μmol/kg/day on days 1 and 2, or on day 11 of a first pregnancy. The antibody was equally effective when injected again during a second pregnancy. There was no evidence for anti-idiotypic antibody production even when the injection of a heterologous (mouse) antibody was repeated in a second pregnancy.
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