Inhibition of post-extraction alveolar ridge resorption in rats by dichloromethane diphosphonate.

Abstract

The therapeutic effect of dichloromethane diphosphonate (C12MDP) on postdental extraction alveolar bone resorption was studied in rats. Rais were injected with 10 mg Cl2MDP/kg/day s.c. for varying intervals from seven days prior to, through 27 days after extraction of maxillary molar teeth. Results demonstrated that C12MDP effectively inhibited rapid alveolar bone loss even after a brief interval of therapy (seven days of therapy prior to extraction), suggesting that the efficacy is not immediately reversible.