Abstract
In normal venules of hamster cheek pouch, platelet thrombogenesis is inhibited by intravenous neuraminidase or by NANA at concentrations (up to 50 μg/ml) produced by neuraminidase from endogenous sources (A. Atherton & G. V.R. Born,1973; J. Physiol., 234, 66P). To find out whether this inhibition also occurs in damaged vessels, venules in hamster cheek pouch or rat mesoappendix were irradiated from a HeNe laser for 5 sec. every min., after an intravenous injection of Evan’s blue (T1824) to absorb the laser energy (I. B. Kovács, A. Tigyi-sebes, K. Trombitas & P. Görög, 1975; Microvasc. Res. , 10, 107). In hamsters, intravenous NANA (10 μg/g body weight) decreased thrombus growth rate after 3 to 9 min. by about 72%. In rats the same dose inhibited thrombogenesis completely for up to 30 min.; 5 μg/g decreased the growth rate. NANA inhibited whether injected at pH 2.3 or 6.0.Under these conditions NANA did not alter blood pH, platelet concentration, or blood flow. Thrombus growth was not inhibited by D-glucuronic acid or by the β-methyl glycoside of NANA at the same molar concentrations as NANA. Therefore, inhibition by NANA of platelet thrombogenesis occurs in damaged as in undamaged vessels.
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