Abstract
Sarcophine, a toxic cembranolide extracted from Sarcophyton glaucum, is known to have toxic effects on fishes, mice and rats, and also reacts with cysteine. Evidence is herewith presented to show that sarcophine inhibits the enzyme phosphofructokinase (ATP: d fructose 6-phosphate 1-phosphotransferase, EC 2.7.1.11) purified from rabbit skeletal muscle. Linear uncompetitive inhibition of the enzyme is indicated due to the reaction of the sarcophine with thiol groups of the enzyme. Sarcophine is shown to be a reversible inhibitor, and a model of the reaction course is offered.
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