Abstract
The effects of daptomycin on exponential phase cells of Bacillus megaterium were investigated. Bacteriostasis was observed for concentrations between 1 and 3 μg/ml and maximal rate of cell lysis at 10 μg/ml. At sublytic concentrations (1.5–3 μg/ml), the variations of the pools of UDP- N-acetylglucosamine and UDP- N-acetylmuramylpentapeptide, as well as the incorporation of ( 14 C)-N- acetylglucosamine into peptidoglycan were studied. From the results it was concluded that the lethal target of daptomycin could be a metabolic step between glucosamine 6-phosphate and UDP- N-acetylglucosamine.
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