Abstract
Thirty of 33 guinea pigs experimentally infected with Trichinella spiralis survived passive systemic anaphylactic reactions which were fatal for 32 of 33 uninfected controls. Guinea pigs were infected with viable excysted trichinella larvae 20 to 32 days before they and uninfected controls were sensitized by intracardiac injection of rabbit anti-bovine serum albumin. Animals were challenged 24 hours later by intracardiac injection of bovine serum albumin. Respiratory anaphylaxis was observed in all challenged animals. Protection from passive anaphylaxis in parasitized guinea pigs was most likely due to preemption of mast cell receptors by parasite-induced antibody with consequent blockage of passive sensitization.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
