Abstract
The anti-ovulatory activity of various intravaginally administered steroids were evaluated using adult female rabbits previously subjected to coitus, an intravenous injection of copper acetate, or human chorionic gonadotrophin. 19-Norprogesterone, chlormadinone acetate and 6-dehydro-progesterone showed significant anti-ovulatory activity at doses of 0.03, 0.03, and 0.1 mg, respectively, when ovulation was induced with copper acetate. Chlormadinone acetate showed a uniquely high anti-ovulatory activity when administered by all three routes: gavage, subcutaneous injection or by intravaginal instillation. Ovulation induced with human chorionic gonadotrophin was not inhibited by 17-acetoxyprogesterone indicating that this steroid does not act at the ovarian level.
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