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Abstract
The enzyme activity and ultrastructure of osteoclasts in medullary bone cultured in the presence of calcitonin were examined using laying hens during the bone resorptive phase when the egg is in the shell gland of the oviduct. Before and after culturing in the absence of calcitonin, osteoclasts on the surface of medullary bone matrix showed strong acid phosphatase (ACP) and succinate dehydrogenase (SDH) activity and moderate lactate dehydrogenase (LDH) activity. These cells had a well-developed ruffled border adjacent to the bone matrix. In the presence of calcitonin, ACP, SDH, and LDH activity of osteoclasts decreased after 12 hours of culturing. The ruffled border disappeared within 1 hour. The clear zone developed near the bone matrix after 12 hours. These results suggest that calcitonin directly inhibits osteoclastic bone resorption in the medullary bone of laying hens during the bone resorptive phase.
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