Abstract
Although no data are recorded, Pereyra1 (on the guinea pig) and Hisaw2 (on the rat) pointed out the fact that inhibition of oestrus was obtained by acid alcoholic extracts of corpus luteum, but neither gave details of procedure. Parkes and Bellerby,3 working on mice, obtained an active preparation by extracting freshly dissected luteal tissue with ether. Macht, et al.,∗ obtained active preparations from de-fatted desiccated luteal tissue both by dilute ethyl alcoholic and by ethyl acetate extraction.Extraction of the oestrus-inhibiting principle from corpora lutea by means of organic solvents has met with varying degrees of success in this laboratory. Press juice gave positive results but there was a severe local reaction and the activity rapidly disappeared. Consistent positive results were obtained with both methyl alcoholic extraction and acidified methyl alcoholic extraction of fresh luteal tissue obtained from sow ovaries. The luteal tissue was hand dissected within 8 hours after removal of the ovari...
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