Inhibition of O-linked glycosylation of CD-44 decreases endometrial cells attachment to peritoneal mesothelial cells

Abstract

OBJECTIVE: CD44, the major glycoprotein ligand for hyaluronan (HA), has multiple N- and O-linked glycosylation sites. We previously demonstrated that abrogation of peritoneal mesothelial cell (PMC) -associated HA inhibits endometrial cell (EC) attachment to PMCs [1] and inhibition of N-linked CD44 glycosylation inhibited EC attachment to PMCs [2]. Here, we assessed the effect of O-linked glycosylation inhibition on EC attachment to PMCs.