Abstract
In this study, lactic acid bacteria (LAB) with antioxidative and probiotic activities were isolated from the vaginas of Korean women and from fermented food. Among 34 isolated LAB strains, four strains (MG4221, MG4231, MG4261, and MG4270) exhibited inhibitory activity against nitric oxide production. The MG4221 and MG4270 strains were identified as Lactobacillus plantarum, and MG4231 and MG4261 were identified as Lactobacillus fermentum. These strains were able to tolerate pepsin and pancreatin, which is required for probiotic potential. The antioxidant effects of culture filtrates obtained from selected strains included 2,2-diphenyl-1-picryl-hydrazyl (DPPH) radical scavenging capacity. Most of the culture filtrates had effective DPPH scavenging activity.In conclusion, the selected strains have significant activities and are potentially applicable to the development of functional foods. These strains might also contribute to the prevention and control of several diseases associated with oxidative stress, when used as functional probiotics.
Highlights
Probiotics are defined as “living microorganisms that have health benefits beyond inherent basic nutrition” when consumed in certain quantities [1,2]
The prebiotic definition according to World Health Organization (WHO)states that “live microorganisms which, when administered in adequate amounts, confer a health benefit on the host” [3,4]
In 2011, a guidance document on scientific requirements for health claims has been published by European Food Safety Authority (EFSA) related to gut and immune function
Summary
Probiotics are defined as “living microorganisms that have health benefits beyond inherent basic nutrition” when consumed in certain quantities [1,2]. The traditional fermented foods have been consumed by millions of people for thousands of years because of their beneficial properties [20] Most of these fermented foods are enriched with bacteria, which has been well reported in previous studies [21,22,23]. Inflammation is a complex reaction of the vascular tissues to harmful stimuli, such as pathogens, damaged cells, or irritants. It is mediated by various signal molecules produced by macrophages, monocytes, and mast cells. We isolated various lactic acid bacteria (LAB) and, after confirming their safety and identity, evaluated their functional characteristics with a focus on their potential application as beneficial probiotic strains
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