Abstract
Angiotensin I and II inhibited the nerve stimulation-induced pressure changes in isolated, perfused rabbit ear atery with an IC 50 of 3.07 and 0.36 nM, respectively. Neither angiotensin I nor angiotensin II affected the basal pressure or the pressure changes elicited by exogenously administered norepinephrine (NE). The potency of angiotensin I was unaltered by 10 −5 M captopril, indicating that conversion by angiotensin converting enzyme (ACE) was not necessary and did not take place. [Sar 1, Val 5, Ala 8]angiotensin II (3 × 10 −8 M) antagonized the effect of angiotensin I. These findings could have implications regarding ACE inhibitor therapy and the pathophysiology of migraine.
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