Inhibition of natidiuretic hormone secretion by intracarotid infusions of slightly hypertonic non-electrolyte solutions.

Abstract

ABSTRACT Relatively rapid (3.75 ml/min), unilateral intracarotid infusions of slightly hypertonic (0.35 m) galactose and glycerol solutions induced a water diuresis within 40 to 60 min in the non-hydrated goat. The response to equi-osmolal fructose solution was weaker and less consistent. The water diuresis was apparently due to an inhibition of the basic ADH secretion, since it could be inhibited temporarily by the administration of small amounts of arginine vasopressin. The corresponding intracarotid infusion of isotonic NaCl solution did not significantly alter the renal clearance of free water, nor did equivalent intrajugular infusions of the non-electrolyte solutions induce water diuresis. The results appear incompatible with the osmoreceptor theory, and support the assumption that a central, Na+ sensitive receptor system may be involved in the regulation of the ADH secretion.