Abstract
AbstractIntravenous injection of l-5-hydroxytryptophan (l-5-HTP), but not l-5-HTP, resulted in an increase in plasma prolactin (PRL) levels in anesthetized rats. l-5-HTP-induced PRL release was blunted by naloxone, a specific opiate antagonist. In rats pretreated with either reserpine or α-methyl-p-tyrosine (α-MT), basal plasma PRL levels were elevated and l-5-HTP injection caused a further increase in plasma PRL concentrations. However, PRL release induced by l-5-HTP was not blunted by naloxone in these animals pretreated with reserpine and α-MT. These results suggest that PRL release induced by serotonin is modulated, at least in part, by opioid peptidergic mechanisms, which are closely related to brain catecholamines.
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Schedule a callMore From: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
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