Inhibition of NADPH Oxidoreductase Promotes Apoptosis in Epithelial Ovarian Cancer Cells

Abstract

Study Objective: To determine the impact of uterine fibroids, particularly large uterine fibroids, on obstetric outcomes. Design: Retrospective study. Setting: University teaching hospital. Patients: Women noted to have uterine fibroids on obstetric ultrasound performed at Hutzel Women’s Hospital beginning September 2009 and who delivered by April 2010 were identified and charts reviewed for demographic information, ultrasound findings, and obstetric outcomes. 39 women who did not have fibroids on ultrasound during the same study period served as controls. Measurements and Main Results: 40 women with fibroids noted on ultrasound delivered during the study period, of which 15 had large fibroids (>5cm). Compared to women with no fibroids or small fibroids, gestational age at delivery was significantly earlier in women with large fibroids (38.5 2.6 vs 36.1 6.3 vs 35.8 4.4 wks, p=.048) and rate of cesarean section was significantly higher (38.5% vs 33.3% vs 66.7%, p=0.43). For women with large fibroids, 10.0% of cesarean sections were elective repeats, compared to 26.7% and 54.5% in women with no fibroids and small fibroids, respectively. Estimated blood loss and rate of blood transfusion were also significantly higher in women with large fibroids, likely due to a higher cesarean section rate in this group. Preterm delivery was associated with number of fibroids >5cm (p=.005) and arrest of labor with total number of fibroids (p\.001). No significant differences between groups were found with respect to placenta previa/accreta, intrauterine growth restriction, short cervix, malpresentation, premature rupture of membranes, chorioamnionitis, endometritis, infant birth weight, Apgar score, and umbilical artery pH. Women with large fibroids had an older maternal age at delivery. Race, gravidity, parity, and BMI were not statistically different between groups. Conclusion:Womenwith pregnancies complicated by large uterine fibroids delivered at an earlier gestational age compared with women with small fibroids or no fibroids. Moreover, the rate of cesarean section was significantly higher in women with large fibroids.