Abstract
In rat brain cortex slices, ethanol was three times more potent in inhibiting [ 3H]noradrenaline ([ 3H]NA) release evoked by N-methyl-D-aspartate (NMDA) than in inhibiting the release evoked by kainic acid. Methanol, 1-propanol, 1-butanol, 1-pentanol and 1-hexanol shared the inhibitory property of ethanol on NMDA-evoked [ 3H]NA release. The inhibitory potency of the alcohols, as expressed by their IC 50 values, was correlated with their membrane/buffer partition coefficient. It is concluded that the inhibitory effect of the alcohols may be due to a hydrophobic interaction with the NMDA receptor system.
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