Abstract
Meeting abstracts CD8 T cells mediate protective immune responses against infections and cancer. Upon infection, antigen-specific naive CD8 T cells are activated and differentiate into short-lived effector (SLEC) and memory precursor cells (MPEC). The T cell intrinsic signaling pathways underlying
Highlights
CD8 T cells mediate protective immune responses against infections and cancer
Inhibition of mammalian target of rapamycin complex 2 (mTORC2)/Akt signaling to enhance the therapeutic potential of CD8 T cells
We show that Rictor, the core component of mammalian target of rapamycin complex 2, regulates short-lived effector (SLEC) and memory precursor cells (MPEC) commitment
Summary
CD8 T cells mediate protective immune responses against infections and cancer. Upon infection, antigenspecific naïve CD8 T cells are activated and differentiate into short-lived effector (SLEC) and memory precursor cells (MPEC). Inhibition of mTORC2/Akt signaling to enhance the therapeutic potential of CD8 T cells Lianjun Zhang1*, Benjamin Tschumi1, Susanne Oberle2, Markus Ruegg3, Michael Hall3, Dietmar Zehn2, Jean-Pierre Mach4, Alena Donda1, Pedro Romero1 From 30th Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2015) National Harbor, MD, USA.
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