Abstract
Flavonoids (103 species) were tested for inhibitory activity against mouse liver sialidase using sodium p-nitrophenyl- N-acetyl-α-D-neuraminate (PNP-NeuAc) as substrate. Isoscutellarein-8- O-glucuronide from the leaf of Scutellaria baicalensis showed most potent activity (IC 50, 40 μM), and this flavone appeared to be a non-competitive inhibitor of the enzyme. This flavone inhibited the lysosomal solubilized sialidase against PNP-NeuAc and sialyllactose effectively, but not microsomal enzyme against gangliosides and colominic acid. whereas, negligible or weak inhibitory activities were observed for influenza virus sialidase, β-galactosidase, α-mannosidase, and α-glucosidase tested. These results indicate that this flavone may be useful to elucidate the function of the lysosomal solubilized sialidase.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
