Abstract
Alkyloxy with or without additional alkyl or hydroxy substituents in the benzene ring considerably enhanced the weak anti-monoamine oxidase activity of 1-phenylethylamine. 1-(3- n-Hexyloxy-4-hydroxy-5- n-propylphenyl) ethylamine had good inhibitory power at 10 −4M at pH 6.8, but the activity declined on the alkaline side of neutrality. It antagonized the prolongation of barbiturate narcosis in mice due to reserpine.
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