Abstract
Natural or recombinant human interferon-γ abolishes the mitogenic activity of platelet-derived growth factor, epidermal growth factor, and fibroblast growth factor on GM2767 or FS-4 human fibroblasts. Similarly murine interferon-γ abolishes the mitogenic activity of these growth factors on BALB/C-3T3 fibroblasts. Inhibition of DNA synthesis by interferon-γ was accomplished by blocking the transition of G 0 G 1 to S phase of the cell cycle. Addition of interferon-γ 15 h after the addition of growth factors (when the cells had already entered the S phase) had no effect on DNA synthesis.
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