Abstract
Purpose: To analyze chloroquine-induced morphological changes in the retinal pigment epithelium (RPE) and Bruch’s membrane (BM). Methods: Retina-choroid complexes of chloroquine-treated Long-Evans rats were analyzed by electron microscopy. Results: Intercellular spaces between the RPE cells and BM were enlarged. Residual material from phagosomes was released into these enlarged spaces. Debris accumulated within BM and encircled choriocapillaris endothelial cells. Conclusion: There is a release of undegraded phagocytic material (rod outer segments) into the extracellular space between BM and RPE cells, following inhibition of lysosomal degradation. Electron-dense deposits in BM and choriocapillaris may lead to reduced oxygen and nutrition flow.
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